Key points from article :
Vaccination against a cell surface marker a viable approach to dealing with senescent cells (SC).
Particularly senescent T cells accumulating in visceral adipose tissues in obese people.
It can spur the rest of the immune system to see them as a problem, seek, then destroy them.
But this could be problematic for wound healing and regeneration, and against cancer.
Cellular senescence is a useful process and is only a problem during ageing.
Vaccine may not be wise unless we are certain that the targeted cells serve no useful function.
Heterogeneity of SC populations causes vaccine's surface marker to only appear on a subset of cells.
So the treatment would be unlikely to target all SC at once.
Further studies needed to test and establish vaccine-based approach.
Researchers from Osaka University Graduate School of Medicine, published in Nature.
