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Thymus regenerated from human cells in mice

Will help treat diseases due to immunodeficiency or autoimmunity

11-Dec-2020

Key points from article :

Human thymus has been built for the first time using human stem cells & a bioengineered scaffold.

Thymus is an organ in the chest where important immune cells mature.

Stem cells were taken from patients who had thymus removed during surgery.

When transplanted into mice they supported the development of mature & functional human immune cells.

".. Crucial step towards being able to grow thymus which could one day be used as transplants" - Sara Campinoti, author.

Thymus helps immune system to recognise self from non-self - poses a problem for organ transplants.

Transplanting a thymus regrown from cells taken from the thymus of the organ donor might prevent this.

Research by The Francis Crick Institute published in Nature Communications.

Mentioned in this article:

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Nature Communications

Journal covering all topics in physics, chemistry, and biology

Sara Campinoti

Post doctoral Researcher at Francis Crick Institute

The Francis Crick Institute

Biomedical discovery institute dedicated to understanding the biology underlying health and disease

Topics mentioned on this page:
Regenerative Medicine, Immunosenescence