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Novel antibody therapy rejuvenates aging immune systems in mice

Potential treatment approach to boost immunity and fight disease in older adults

27-Mar-2024

Key points from article :

Scientists developed an antibody therapy that rejuvenates immune systems in old mice.

The treatment targets blood stem cells that become unbalanced with age.

A week after receiving an antibody injection, the mice had about 38% fewer of these aberrant stem cells.

Vaccinated treated mice fought off a virus infection better than untreated mice.

Similar therapy might be possible in humans, but with potential side effects.

“By rejuvenating or improving immune function in older people, that could really help with fighting off infections,” - Robert Signer at UC San Diego.

“You might also have an impact on different types of chronic inflammatory diseases.”

This research is a promising step towards boosting immunity in older adults.

Study by Stanford University School of Medicine, published in the journal Nature.

Mentioned in this article:

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Nature

Scientific journal covering research from a variety of academic disciplines, mostly in science and technology

Robert Signer

Stem cell biologist and Assistant professor at University of California San Diego

Stanford University School of Medicine

Medical school that improves health through discoveries and innovation in health care, education and research

Topics mentioned on this page:
Immunosenescence, Stem Cells
Novel antibody therapy rejuvenates aging immune systems in mice