Key points from article :
SIRT6 also called “longevity sirtuin” has been making rather a name for itself.
SIRT6 is a protein vital for both normal base excision repair and double-strand break repair of DNA damage that can lead to genomic instability, contributing to aging.
SIRT6 recruits PARP1, which acts as a ‘first responder’, detecting DNA damage and facilitating the choice of repair pathway.
The rodent trial uses a control group that is taking a placebo, and another group was given SIRT6Activator.
The mice that received SIRT6Activator had significantly lower frailty scores.
Longevity supplement company DoNotAge.org launched a SIRT6 activator product.
Vera Gorbunova, lead researcher told, “Epigenetic reprogramming is very powerful, SIRT6Activator is a safe way to repair the epigenome.”
The tests were carried out at the Gorbunova Aging Research Center at the University of Rochester.