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Metformin alleviates inflammaging by promoting autophagy

14-May-2020

Key points from article :

New study has shown metformin ameliorates inflammaging by promoting autophagy.

TH17 subset of cytokines is strongly associated with inflammaging.

RNA silencing was used to disrupt the ability of cultured cells to engage in autophagy.

Young subject's cells had their mitochondrial function decreased to an older person's level.

Also set the TH17 cytokine profile of these cells to become one associated with age, diabetes.

Metformin able to accomplish this in human cell cultures.

By spurring autophagy and reversing the TH17 cytokine profile.

This is a cell culture study, hopes are up for human trials and its success.

Published in Cell Metabolism.

With the positive results, drug holds great promise for promoting healthy ageing

Mentioned in this article:

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Journal

Scientific Journal providing information from many different areas of metabolism.

Academia

College in Massachusetts