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mRNA delivers mutated proteins - regenerates cardiomyocytes post a heart attack


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Researchers at the University of Houston discovered  a ‘Powerful Clinical Strategy’ for treating heart disease.

Not only repairs heart muscle cells in mice but also regenerates them following a heart attack, or myocardial infarction.

Uses synthetic messenger ribonucleic acid (mRNA) to deliver mutated transcription factors - to mouse hearts.

Two mutated transcription factors, Stemin and YAP5SA, work in tandem to increase the replication of cardiomyocytes.

Stemin turns on stem cell-like properties from cardiomyocytes and YAP5SA works by promoting organ growth.

Professor at the UH, Robert Schwartz said: "...hearts over the next month were repaired to near normal cardiac pumping function with little scarring.”

According to his Ph.D student added benefit is it disappears in a few days as opposed to viral delivery.

The findings are especially important because less than 1% of adult cardiac muscle cells can regenerate.

Research at University of Houston, published in  The Journal of Cardiovascular Aging.

Stemin and YAP5SA notably restores normal cardiac pumping in mice

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Professor of biology and biochemistry at University of Houston


International peer-reviewed, open access, online journal in aging and cardiovascular disease


Public research university.

mRNA delivers mutated proteins - regenerates cardiomyocytes post a heart attack