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mRNA delivers mutated proteins - regenerates cardiomyocytes post a heart attack

16-Jun-2022

Key points from article :

Researchers at the University of Houston discovered  a ‘Powerful Clinical Strategy’ for treating heart disease.

Not only repairs heart muscle cells in mice but also regenerates them following a heart attack, or myocardial infarction.

Uses synthetic messenger ribonucleic acid (mRNA) to deliver mutated transcription factors - to mouse hearts.

Two mutated transcription factors, Stemin and YAP5SA, work in tandem to increase the replication of cardiomyocytes.

Stemin turns on stem cell-like properties from cardiomyocytes and YAP5SA works by promoting organ growth.

Professor at the UH, Robert Schwartz said: "...hearts over the next month were repaired to near normal cardiac pumping function with little scarring.”

According to his Ph.D student added benefit is it disappears in a few days as opposed to viral delivery.

The findings are especially important because less than 1% of adult cardiac muscle cells can regenerate.

Research at University of Houston, published in  The Journal of Cardiovascular Aging.



Stemin and YAP5SA notably restores normal cardiac pumping in mice

Mentioned in this article:

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Academic

Professor of biology and biochemistry at University of Houston

Journal

International peer-reviewed, open access, online journal in aging and cardiovascular disease

Academia

Public research university.

mRNA delivers mutated proteins - regenerates cardiomyocytes post a heart attack