Key points from article :
Levels of NAD+ available decline significantly with age.
Researchers treated aged mice with NAD+ precursor, NMN, for two weeks.
There was a difference in gene expression between young and old mice.
204 of 590 genes affected were reversed by NMN back to youthful expression levels.
NMN increased NAD+ in old mice, which activated SIRT1 (a longevity-associated gene).
Further analysis showed that NMN has a neurovascular protective effect.
Inhibition of CD38 could also restore NAD+ levels in aged animals.
Race to bring the first effective mitochondrial rejuvenation treatment through human trials.
Published in GeroScience.
