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Copying naked mole-rat living conditions can extend lifespan

06-Aug-2020

Key points from article :

Ukrainian-Israeli collaboration has taken the first step toward emulating naked mole-rat (NMR).

Mice placed in conditions of low oxygen, high carbon dioxide, like NMR tunnels.

Significantly lower the rodents’ body temperature, slow their metabolism for as long as months.

First time science achieved almost permanently slower metabolic rate in any warm-blooded animal.

Based on observation, metabolically slow NMRs live 8 times longer than similar rodents.

The mice also observed to voluntarily ate less and skin wounds healed faster.

No significant changes in expression of stress-related genes.

“Small differences in temperature can lead to major changes in life span.”

Chronic exposure to hypoxic-hypercapnic environment is a potential intervention to extend lifespan.

As well as a tool for treating human obesity and associated metabolic disorders, team concludes.

Researchers from Ben-Gurion University of the Negev and Institute of Gerontology, Ukraine.

Published in the journal of Biogerontology.

Demonstrated in mice, far from human trials, but a potential longevity intervention

Mentioned in this article:

Academia

Research university in Israel

Journal

Journal on biological mechanisms of ageing

Institute

Research institution, Ukraine

Academic

Professor, Institute of Gerontology (Ukraine)

Academic

Staff Scientist/ Senior Principal Investigator, Calico

Academic

Senior Researcher, Ben-Gurion University of the Negev