Key points from article :
A groundbreaking study by Kyushu University researchers demonstrates the potential to restore brain function after stroke by converting microglia, the brain's immune cells, into neurons.
Stroke often leads to permanent damage due to the limited regenerative capacity of neurons.
This novel approach offers hope for replacing lost neurons and improving recovery.
Microglia, abundant at injury sites, were targeted for conversion into neurons using a protein called NeuroD1.
In mice with stroke-like injuries, the conversion of microglia into neurons led to a remarkable decrease in neuron loss and improved motor function.
The study highlights the therapeutic potential of microglial conversion for stroke treatment, paving the way for further research in human applications.
The findings, published in PNAS, underscore the need to investigate the safety and efficacy of this approach in human trials.
