Key points from article :
NAD+ (nicotinamide adenine dinucleotide), a key metabolite to an efficient and healthy metabolism, declines with age.
Scientists have been unaware that whether the decline stems from decreased production of NAD+, a problem with “faucet,” or from its degradation, an issue akin to a “leaky sink”.
“Supplementation will be part of the equation, but filling the sink without dealing with the leak will be insufficient” - Eric Verdin.
Preliminary data suggests that blocking CD38 activity in older animals restores NAD+ levels in specific tissues.
Senescent cells spew pro-inflammatory proteins, called senescence-associated secretory phenotype (SASP).
“Inflammatory proteins in the SASP induce macrophages to proliferate, express CD38 and degrade NAD+” - Anthony Covarrubias, author.
"NAD+ is important to cellular health and we look forward to applying this discovery to stem the ravages of age-related disease” - Verdin.
Study by Buck institute published in Nature metabolism.