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A low-calorie diet maintains youthful gut state & improves lifespan

24-Mar-2021

Key points from article :

The first and most studied manipulation to increase lifespan in mammals is caloric restriction (CR).

Reducing food consumption by 30% to 50% increases both the mean and maximum lifespans of both laboratory rats and mice.

Shown to increase the lifespan of diverse animal models from invertebrates to dogs and non-human primates.

Life-long CR increased microbial diversity and Bacteroidetes/Firmicutes ratio and prevented age-related changes.

Old mice fed CR were enriched in the Rikenellaceae, S24-7, and Bacteroides families.

Changes were initiated in the cecum and further modified in the colon.

Short-term CR in adult mice had a minor effect on the microbiome but a major effect on the transcriptome of the colon mucosa.

CR has a major impact on the gastrointestinal system, which could result in a more diverse and youthful microbiome.

Study published in the Journal Aging.

Calorie restriction prevents age-related changes to the gut microbiome in mice

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Aging

Bio-medical journal covering research on all aspects of gerontology