Key points from article :
The first and most studied manipulation to increase lifespan in mammals is caloric restriction (CR).
Reducing food consumption by 30% to 50% increases both the mean and maximum lifespans of both laboratory rats and mice.
Shown to increase the lifespan of diverse animal models from invertebrates to dogs and non-human primates.
Life-long CR increased microbial diversity and Bacteroidetes/Firmicutes ratio and prevented age-related changes.
Old mice fed CR were enriched in the Rikenellaceae, S24-7, and Bacteroides families.
Changes were initiated in the cecum and further modified in the colon.
Short-term CR in adult mice had a minor effect on the microbiome but a major effect on the transcriptome of the colon mucosa.
CR has a major impact on the gastrointestinal system, which could result in a more diverse and youthful microbiome.
Study published in the Journal Aging.
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