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Regenerative therapies and senolytics help to rejuvenate the heart’s capacity to regenerate

Eliminating senescent cells rejuvenates the heart's capacity for regeneration in mice

17-Aug-2022

Key points from article :

Prof Georgina Ellison-Hughes said, "targeting cell senescence using senolytics can rejuvenate the aged heart’s regenerative capacity".

“We’ve used the drugs Dasatinib and Quercetin to eliminate senescent cells, in an aged mouse model, you see a rejuvenation of the heart’s regenerative potential,” she says. 

“Today, 50% of your cardiac stem progenitor cells become senescent by the time you’re 75, so you’ve lost 50% capacity for regeneration,” she says. 

“Activates the cardiac stem progenitor cells, cardiomyocyte proliferation, and decreased cardiac hypertrophy and fibrosis.”

She is also looking at another potential paper on the effects of senolytics specifically on senescent cardiomyocytes.

“Rather than eliminating senescent cells, we’re also looking at reverting their phenotype,” she explains.


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Georgina Ellison-Hughes

Professor of Regenerative Muscle Physiology at King's College London specializing in stem cell science, exercise scientist and physiology

King's College London

Public research university

Longevity Leaders World Congress 2022

26-Feb-2022 to 27-Feb-2022

Event for leaders in longevity science, technology, business and finance organized by Longevity Leaders (LSX)

Topics mentioned on this page:
Senescent Cells, Heart Disease
Regenerative therapies and senolytics help to rejuvenate the heart’s capacity to regenerate