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Regenerative therapies and senolytics help to rejuvenate the heart’s capacity to regenerate

17-Aug-2022

Key points from article :

Prof Georgina Ellison-Hughes said, "targeting cell senescence using senolytics can rejuvenate the aged heart’s regenerative capacity".

“We’ve used the drugs Dasatinib and Quercetin to eliminate senescent cells, in an aged mouse model, you see a rejuvenation of the heart’s regenerative potential,” she says. 

“Today, 50% of your cardiac stem progenitor cells become senescent by the time you’re 75, so you’ve lost 50% capacity for regeneration,” she says. 

“Activates the cardiac stem progenitor cells, cardiomyocyte proliferation, and decreased cardiac hypertrophy and fibrosis.”

She is also looking at another potential paper on the effects of senolytics specifically on senescent cardiomyocytes.

“Rather than eliminating senescent cells, we’re also looking at reverting their phenotype,” she explains.


Eliminating senescent cells rejuvenates the heart's capacity for regeneration in mice

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Georgina Ellison-Hughes

Professor of Regenerative Muscle Physiology at King's College London specializing in stem cell science, exercise scientist and physiology

King's College London

Public research university

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Regenerative therapies and senolytics help to rejuvenate the heart’s capacity to regenerate