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Scientists at Paris-based startup Robeauté have developed tiny robots, about the size of a grain of rice, capable of navigating the human brain to diagnose and treat neurological conditions. These microrobots offer a minimally invasive alternative to traditional neurosurgical methods, which rely on stiff tools that can cause significant damage. The innovation, heralded as revolutionary, could reshape brain treatments much like the endoscope transformed gastrointestinal medicine.
Introduced through a tiny burr hole just 3mm wide, the microrobots move through the brain’s extracellular matrix in curved paths, guided by a neurosurgeon and tracked in real-time. This precision allows them to access hard-to-reach areas while minimizing damage to surrounding tissues. These versatile robots are equipped with self-powered engines and can carry extensions for various tasks, including tumour biopsies, drug delivery, electrode implantation, and data collection.
Animal tests have already demonstrated the potential of these microrobots, particularly in collecting critical biopsy information to guide treatment decisions. Co-founder Joana Cartocci explained that while biopsies are diagnostic, they pave the way for effective, targeted therapies to follow. Looking ahead, the startup aims to begin human trials in 2025 and is working with regulatory authorities to bring the technology into neurosurgical practice. If trials succeed, Robeauté anticipates regulatory approval for drug delivery applications by 2030, unlocking new possibilities for personalized, precision medicine in neurology.
