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CRISPR gene editing to help immune cells target and kill cancer


Key points from article :

Many cancers involving blood cells now treated by removing immune cells.

Then adding a gene that makes them target cancer cells and putting them back.

Virus, used to add a gene to make the immune cells target tumour protein.

CRISPR gene-edited immune cells injected into three people with advanced cancer.

Participants given just a dose of gene-edited cells.

Three genes, were deleted using CRISPR, patients survived for 9 months.

Trial won’t continue because its 2016 gene-editing technology is already outdated,

New CRISPR called base editing, to inactivate genes without cutting DNA.

There are many other ways to edit immune cells to make them more effective.

Research by University of Pennsylvania, published in Science.

First CRISPR cancer trial in the world publish its promising findings

Mentioned in this article:

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Edward Stadtmauer

Section Chief, Hematologic Malignancies, Perelman School of Medicine, University of Pennsylvania

Great Ormond Street Hospital (GOSH)

Children's hospital for special care.

Science News

Magazine devoted to short articles about new scientific and technical developments

UCL Great Ormond Street Institute of Child Health

Academic department of the Faculty of Population Health Sciences, University College London (UCL)

University of Pennsylvania

Private Ivy League research university in Philadelphia, Pennsylvania.

Waseem Qasim

Professor of Cell and Gene therapy, Consultant Immunologist, Great Ormond Street hospital