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Immune system clock tracks health, age-related disorders, and longevity

12-Jul-2021

Key points from article :

The inflammatory clock of aging (iAge) measures inflammatory load and predicts multi-morbidity, frailty, immune health, cardiovascular aging.

"Identified the soluble chemokine CXCL9 as the strongest contributor to iAge," - Nazish Sayed, first author.

“CXCL9 is involved in cellular senescence, vascular aging and adverse cardiac remodeling,” - Sayed.

“Centenarians have an immune age that is 40 years younger and a super-healthy 105 year-old man has the immune system of a 25 year old,” - David Furman, senior study author.

"The tool can be used to track risk of developing multiple chronic diseases by assessing the cumulative physiological damage to immune system," - Furman.

“We have to pay more attention to the immune system with age, given that almost every age-related malady has inflammation as part of its etiology,” - Furman.

Furman says, “I think of inflammation as the 10th hallmark” of the ageing process.

Research by Buck Institute and Stanford University published in Nature Aging.

Measuring immune health with a chemokine, CXCL9, for early disease interventions

Mentioned in this article:

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Institute

Independent biomedical research institute focused on aging

Academic

Director of the Buck Artificial Intelligence Platform & Stanford 1000 Immunomes Project.

Journal

Journal spanning the entire spectrum of research into aging

Academic

Assistant Professor at Stanford University