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Comprehensive history and explanation of senescent cells

01-Mar-2020

Key points from article :

Senescent cells, appears to play seemingly opposing roles in vivo.

Proven a driver of the physical decline characteristic of old age.

Transplanting accelerated most or all of diseases mice die of in old age.

Inflammation, stem cell exhaustion, among its significant consequences in ageing tissues.

Destroying it slows down age-related physical decline, boost overall health.

Concept of senolytics will stand the test of time, unlike other 'elixirs of youth'.

Good side of senescent cells as developmental and cancer prevention mechanism, viewed.

But it came with a tradeoff of the damage it can cause as they accumulate with age.

Initial trials of senolytic drug candidates all moving forward with positive results.

Experiments have increased rodents’ median lifespan.

But eliminating senescent cells couldn’t extend the maximum lifespan of the animals.

Including the latest on clinical trials of first-generation senolytics

Mentioned in this article:

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Academic

Principal Investigator, Institute of Genetics and Molecular and Cellular Biology

Company

Ensuring safety of drugs, medical supplies and food which is used daily.

Academic

Director of the Division of Aging Biology at the National Institute on Aging

Academic

Researcher on different aging related diseases.

Academic

Professor of Biochemistry and Molecular Biology and Professor of Pediatrics at The Mayo Clinic.

Company Representative

Chief Executive Officer of Amazon.

Academic

Morton Goldberg Professor, Johns Hopkins University

Academic

Professor of biogerontology and Biochemist.

Company Representative

Chairman and CEO of UNITY Biotechnology.

Academic

Professor of Anatomy, University of California

Academic

Professor of Molecular Genetics at the University of Exeter.

Academic

Director, Institute for Research in Biomedicine

Academic

Co-Founder and President, Unity Biotechnology

Institute

Conducting and supporting research on aging and the health and well-being of older people.

Academic

Professor of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota.

Author

American entrepreneur and venture capitalist.

Academia

UK university and member of the Russell Group of leading research-intensive UK universities

Academia

Public Research university.