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Comprehensive history and explanation of senescent cells


Key points from article :

Senescent cells, appears to play seemingly opposing roles in vivo.

Proven a driver of the physical decline characteristic of old age.

Transplanting accelerated most or all of diseases mice die of in old age.

Inflammation, stem cell exhaustion, among its significant consequences in ageing tissues.

Destroying it slows down age-related physical decline, boost overall health.

Concept of senolytics will stand the test of time, unlike other 'elixirs of youth'.

Good side of senescent cells as developmental and cancer prevention mechanism, viewed.

But it came with a tradeoff of the damage it can cause as they accumulate with age.

Initial trials of senolytic drug candidates all moving forward with positive results.

Experiments have increased rodents’ median lifespan.

But eliminating senescent cells couldn’t extend the maximum lifespan of the animals.

Including the latest on clinical trials of first-generation senolytics

Mentioned in this article:

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Principal Investigator, Institute of Genetics and Molecular and Cellular Biology


Ensuring safety of drugs, medical supplies and food which is used daily.


Director of the Division of Aging Biology at the National Institute on Aging


Researcher on different aging related diseases.


Professor of Biochemistry and Molecular Biology and Professor of Pediatrics at The Mayo Clinic.

Company Representative

Chief Executive Officer of Amazon.


Morton Goldberg Professor, Johns Hopkins University


Professor of biogerontology and Biochemist.

Company Representative

Chairman and CEO of UNITY Biotechnology.


Professor of Anatomy, University of California


Professor of Molecular Genetics at the University of Exeter.


Director, Institute for Research in Biomedicine


Co-Founder and President, Unity Biotechnology


Conducting and supporting research on aging and the health and well-being of older people.


Professor of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota.


American entrepreneur and venture capitalist.


UK university and member of the Russell Group of leading research-intensive UK universities


Public Research university.