Key points from article :
Senescent cells, appears to play seemingly opposing roles in vivo.
Proven a driver of the physical decline characteristic of old age.
Transplanting accelerated most or all of diseases mice die of in old age.
Inflammation, stem cell exhaustion, among its significant consequences in ageing tissues.
Destroying it slows down age-related physical decline, boost overall health.
Concept of senolytics will stand the test of time, unlike other 'elixirs of youth'.
Good side of senescent cells as developmental and cancer prevention mechanism, viewed.
But it came with a tradeoff of the damage it can cause as they accumulate with age.
Initial trials of senolytic drug candidates all moving forward with positive results.
Experiments have increased rodents’ median lifespan.
But eliminating senescent cells couldn’t extend the maximum lifespan of the animals.