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New investigational drug shows promise in reversing age-related liver damage

Blocking cell death pathway rejuvenates livers in mice, offering potential treatment for humans

26-Jun-2024

Key points from article :

Livers can be damaged by stress and aging, leading to disease, severe scarring and failure.

Researchers found a way to potentially reverse liver damage in mice.

"Aging promotes a type of cell death in hepatocytes called ferroptosis, which is dependent on iron," - Anna Mae Diehl, senior author.

Human fatty livers also showed signs of increased ferroptosis, amplifyng stress in other tissues.

A drug called Ferrostatin-1 blocked this cell death pathway in mice.

Livers of the treated mice looked biologically like young, healthy livers.

This suggests reversal of age-related liver damage might be possible.

Research by Duke University, published in the journal Nature Aging.

Mentioned in this article:

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Anna Mae Diehl

Florence McAlister Distinguished Professor of Medicine at Duke University School of Medicine

Duke University

Private research university in Durham, North Carolina

Nature Aging

Journal spanning the entire spectrum of research into aging

Topics mentioned on this page:
Liver Disease, Rejuvenation
New investigational drug shows promise in reversing age-related liver damage