Key points from article :
Diet has been directly linked to microbiota composition in humans and rodents.
"A healthy microbiota helps ensure that tryptophan produce serotonin and melatonin," - Sadanand Fulzele, co-corresponding author.
“Microbiome plays an important role in the aging...tryptophan...affect every organ function,” - Carlos M. Isales, co-corresponding author.
Fed the aged mice three different diets for 8 weeks - diets that were deficient, recommended levels and high levels of tryptophan.
A low-tryptophan diet results in unhealthy changes in the gut microbiota and high systemic inflammation.
Mice on a tryptophan-rich diet had higher levels of the calming IL-27.
"When resumed a healthy tryptophan intake, some of the unhealthy changes resolved in just a few days," - Fulzele.
A better option is giving metabolites early, rather than attempting a tryptophan rescue.
Study by Augusta University published in International Journal of Molecular Sciences.
