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Lack of gene coordination during aging calls for newer treatments

Researchers found a new link in aging from a 15yr old approach

03-Nov-2020

Key points from article :

The potential to develop treatments for aging depends on the fundamental process of growing old.

A common approach holds that most cells are barely damaged, while a small fraction of cells are significantly damaged.

Using a novel approach from physics, researchers measured the gene activity and compared cells from old and young subjects.

Discovering old cells lost significant coordination levels compared to young cells.

To test the consistency, they analyzed data among different organisms, different cell types.

"In biology it is very difficult to achieve consistent results" - Dr. Orr Levy, lead author.

Findings support the theory that random damage disrupts the ability of genes to coordinate (resulting in a decrease in tissue function).

If the same level of coordination reduction between genes is indeed a leading cause for aging phenomena, there may be a need to change course in current efforts to develop aging treatments.

Research by Bar Ilan University published in Nature metabolism.

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Bar Ilan University

Public research university.

Nature Metabolism

Online journal Nature Metabolism is an online journal of Nature Research

Orr Levy

System engineer, Researcher, Bar-Ilan University

Topics mentioned on this page:
Ageing Research