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Mice regain vision through partial cellular reprogramming of retinal cells

While age ultimately caught up, study demonstrates potential of the novel treatment


Key points from article :

Scientists used 3 of the 4 Yamanaka factors (OSK) to partially reprogram retinal cells in mice with glaucoma.

After treatment, mice showed significantly restored vision, even surpassing baseline levels for a while.

The effect lasted longer in mice with continuous OSK expression compared to those with induced expression (controlled by a drug).

The researchers believe the vision decline after an initial peak in both groups was likely due to the mice's overall ageing, not a loss of the treatment's effect.

No tumors or changes in retinal structure were observed, indicating the safety of this approach in this model.

While promising, this study was in mice, and more research is required before applying it to humans with glaucoma.

The research was led by Dr. David Sinclair from Harvard findings of the research are published in Cellular Reprogramming

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Cellular Reprogramming

Journal dedicated to cellular reprogramming mechanisms, technologies and applications

David Sinclair

Chief Executive at International Longevity Centre UK

Harvard University

Private Ivy League research university in Massachusetts

Topics mentioned on this page:
Vision (health), Rejuvenation
Mice regain vision through partial cellular reprogramming of retinal cells