Yamanaka factors plus 2 more resets cells age without destroying their identity
Epigenetic alterations is one of the standard hallmarks of aging.
The alterations to gene expression harm the fundamental functions of our cells.
Changes to methylation patterns can:
- decrease the amount of heterochromatin
- increase chromosome fragility
- multiply transcriptional alterations
- increase remodeling of chromatin
- amplify transcriptional noise.
Stanford University researchers have ameliorated cellular aging, including resetting of epigenetic clock.
Used transient expression of nuclear reprogramming factors, mediated by expression of mRNAs.
This also reduced the inflammatory profile in chondrocytes.
Restored human muscle stem cells without abolishing cellular identity.
Separates the resetting of cellular aging from the resetting of cell identity.
Researchers used the four Yamanaka factors (OSKM) plus LIN28 and Nanog, to make OSKMLN.
Have formed Turn Biotechnologies to develop therapies for osteoarthritis and other age-related diseases.
Mentioned in this article:
Turn.bio - Company dedicated to Reversing Aging by Reprogramming Cells.