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DNA repair and metabolism as determinants of species longevity

22-Nov-2016

Key points from article :

Mammalian lifespan differs by >100-fold

Skin fibroblasts from 16 species of mammals studied under identical cell culture conditions.

Key features of cells from longer-lived species:

1. up-regulated genes involved in DNA repair and glucose metabolism

2. down-regulated proteolysis and protein transport

3. high levels of amino acids but low levels of lysophosphatidylcholine and lysophosphatidylethanolamine

Mentioned in this article:

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Vadim Gladyshev

Professor of Medicine at Harvard Medical School

Topics mentioned on this page:
Rejuvenation