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LEAF interviews the Conboys about rejuvenating mice by diluting blood plasma

This could be a cheap first generation rejuvenation treatment - but wait for clinical trials

16-Jun-2020

Key points from article :

Drs. Irina and Michael Conboy's new study replaced half of the blood plasma in old mice with a saline and albumin mixture.

Excessive factors in old blood may be elevated good proteins that become counterproductive (e.g. TGF beta).

Experiment saw less fibrosis in muscles and liver, and showed therapeutic effects on fibrotic diseases.

Hippocampal neurogenesis increased eightfold (area of the brain responsible for learning and memory).

Young factors don’t disappear from our bodies - they’re suppressed by the age-elevated proteins.

If you dilute young blood, mammals should become older because you have diminished their young factors. That didn't happen.

Dr. Kiprov's therapeutic plasma exchange (TPE) treatment anecdotally reports improved immunity.

Alkahest's blood scrubber is designed to remove B2M from the blood - but doesn't increase in bloodstream with age.

Interested in healthspan - not how long a mouse can live.

WARNING: do not go somewhere and get your blood replaced with saline.

Mentioned in this article:

Click on resource name for more details.

Alkahest

Biotechnology company focused on treating neurodegenerative and other age-related diseases

Irina Conboy

Professor of Bioengineering at Berkeley University of California.

Michael Conboy

Lecturer in Department of Bioengineering at Berkley University of California.

University of California, Berkeley

Public land-grant research university

Topics mentioned on this page:
Young Blood, Rejuvenation