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Balancing blood iron levels is the key to living longer

Genes linked to iron metabolism were also responsible for age related diseases

16-Jul-2020

Key points from article :

Biological ageing varies between people and drives the world's most fatal diseases.

Data from more than a million people suggests that healthy levels of iron in the blood could be a key to living longer.

Scientists focused on lifespan, years of life lived free of disease (healthspan), and extremely long-lived (longevity).

Found gene sets linked to iron were overrepresented in all three measures.

Blood iron is affected by diet and abnormally high or low levels are linked to age-related conditions.

Researchers design a drug that mimic the influence of genetic variation on iron metabolism.

"Our findings also explain high levels of iron-rich red meat has been linked to age-related conditions" - Paul Timmers, Coauthor.

"Ten regions of the genome we discovered are all exciting candidates for further studies" - Joris Deelen, Lead author.

Research by University of Edinburgh and the Max Planck Institute for Biology of Ageing published in Nature Communications.

Mentioned in this article:

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Joris Deelen

Geneticist and Research Group leader at the Max Planck Institute for Biology of Ageing

Max Planck Institute for Biology of Ageing

Scientific research institute dedicated to age research

Nature Communications

Journal covering all topics in physics, chemistry, and biology

Paul Timmers

Postdoctoral data analyst affiliated with the Usher Institute and the MRC Human Genetics Unit.

The University of Edinburgh

Public research university for UK and international students

Topics mentioned on this page:
Longevity Genes