Join the club for FREE to access the whole archive and other member benefits.

PF4: the tiny protein that could boost your brain power, no matter your age

PF4 from platelets enhanced learning and memory in both young and old mice

16-Aug-2023

Key points from article :

Researchers at UCSF and the University of Queensland, led by Saul Villeda, have discovered a protein called platelet factor 4 (PF4) that rejuvenates the old brain and boosts the young brain.

PF4 is released by blood platelets and is thought to work by calming down the aged immune system and promoting new neural connections.

Injections of PF4 from the blood of young mice into old mice improved their performance on memory and learning tasks.

PF4 also boosted brain function in young mice, suggesting that there is room to improve cognitive function even in younger brains.

The researchers are hopeful that their findings could lead to new therapies for age-related cognitive decline.

The findings are published in three different journals Nature, Nature Aging, and Nature Communications.

Mentioned in this article:

Click on resource name for more details.

Nature

Scientific journal covering research from a variety of academic disciplines, mostly in science and technology

Nature Aging

Journal spanning the entire spectrum of research into aging

Nature Communications

Journal covering all topics in physics, chemistry, and biology.

University of California, San Francisco (UCSF)

Public research university that is part of the University of California system and dedicated entirely to health science

University of Queensland

Public Research university.

Topics mentioned on this page:
Young Blood, Mental Health
PF4: the tiny protein that could boost your brain power, no matter your age