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Underlying mechanisms of how cellular senescence leads to neurodegeneration

Cellular senescence is now a top research topic and a very messy one in ageing research

29-Jan-2020

Key points from article :

Senescence in astrocytes leads to damaging “excitotoxicity” in cortical neurons that are involved in memory.

Cellular senescence in astrocytes downregulates the glutamate transporters.

Clearing senescent cells prevented Parkinson’s in a mouse model of the disease.

Many factors secreted by senescent astrocytes could be exploited as a way to treat glioblastoma.

Research involved unbiased RNA sequencing of transcripts expressed by senescent and non-senescent astrocytes.

Mentioned in this article:

Click on resource name for more details.

Buck Institute

Independent biomedical research institute focused on aging

Campisi lab

Campisi lab studies the regulation and characteristics of cell states, with an emphasis on cellular senescence

Chandani Limbad

Research scientist at Buck Institute for Research on Aging

PLOS ONE

This journal covers primary research from any discipline within science and medicine.

Topics mentioned on this page:
Senescent Cells, Mental Health