Key points from article :
Senescence in astrocytes leads to damaging “excitotoxicity” in cortical neurons that are involved in memory.
Cellular senescence in astrocytes downregulates the glutamate transporters.
Clearing senescent cells prevented Parkinson’s in a mouse model of the disease.
Many factors secreted by senescent astrocytes could be exploited as a way to treat glioblastoma.
Research involved unbiased RNA sequencing of transcripts expressed by senescent and non-senescent astrocytes.
