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Extracellular vesicles from young stem cells have a rejuvenating effect in vitro and in vivo in mice

08-Nov-2022

Key points from article :

Injection of extracellular vesicles secreted by young adipose-derived stem cells increases fitness and promotes tissue rejuvenation in aged mice.

Small extracellular vesicles are one of the ways in which cells communicate with each other.

They chose young adipose-derived (taken from fat tissue) stem cells as their donor cells. 

Two doses of small extracellular vesicles secreted by those cells were injected into naturally aged mice one week apart.

These vesicles restore senescent cells instead of killing them (senomorphic).

The data was collected during the one-month follow-up period.

The treated mice showed greatly improved fitness.

The researchers also performed histological analyses of kidneys and muscles.

Treated animals also showed less fat deposition in muscles, which indicates better function.

The researchers also measured the epigenetic age of the tissues showing robust age reversal in kidneys but not in muscle.

The study by University of Valencia was published in Science Advances.

This approach did not kill the senescent cells instead, it was senomorphic

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Science Advances

Journal that publishes original research and reviews in all disciplines of science

University of Valencia

Public research university in Valencia, Spain.