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Stem cells from a 110-year-old women open doors to aging research

Scientists created stem cells from supercentenarian for the first time, calling it "super sauce"

20-Mar-2020

Key points from article :

People who live more than 110 years (supercentenarians) are remarkable because of their age, incredible health.

Resistant to diseases such as Alzheimer's, heart disease and cancer that still affect even centenarians.

For the first time, scientists have reprogrammed cells from a 114-year-old woman into induced pluripotent stem cells (iPSCs).

Reprogrammed blood cells from 114 year old woman, a healthy 43-year-old individual and an 8-year-old child with progeria.

Cells were then transformed into mesenchymal stem cells that helps maintain and repair the body's structural tissues.

Supercentenarian cells transformed as easily as the cells from the healthy and progeria samples.

Telomeres of the supercentenarian iPSCs were reset to youthful levels.

"We have a valuable tool for finding genes and other factors that slow down the aging process." - Evan Snyder, senior author.

Research by Sanford Burnham Prebys, AgeX Therapeutics published in Biochemical and Biophysical Research Communications.

Mentioned in this article:

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AgeX Therapeutics

Biotechnology company focused on the development of novel therapeutics for age-related degenerative disease

Biochemical and Biophysical Research Communications

Peer-reviewed scientific journal on Biochemistry and Biophysics

Evan Snyder

Professor at Sanford Burnham Prebys Institute & Dept. of Pediatrics

Sanford Burnham Prebys Medical Discovery Institute

Conducts collaborative research to find new therapies and improve quality of life

Topics mentioned on this page:
Stem Cells, Centenarians