Key points from article :
Exposing young cells to aged blood causes their gene expression to become akin to aged cells.
Aged blood causes negative effects in human cells and is linked to systemic ageing.
RNA analysis shows that hundreds or thousands of genes are altered, depending on cell type.
Hepatocytes have 600 differentially expressed genes (DEGs) when exposed to aged blood.
Whereas aged hepatocytes exposed to young blood have a 1000 gene expressions restored to a youthful state.
Endothelial cells, hematopoietic stem cells (HSCs) & mesenchymal stromal cells(MSC) are also affected.
Accelerated ageing has much in common with normal ageing.
60%, 80% and 94% of the changes that occur in MSCs, HSC and oligodendrocytes respectively due to exposure to aged blood are identical to that of normal ageing.
Accumulation of visceral fat in obesity produces pro-ageing blood protein.
Replacing these pro ageing factors with youthful ones might help in systemic rejuvenation.
Research by Stanford University published in Nature Medicine.
