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Telomeres are different lengths than scientists previously thought

This could transform how we approach diseases linked to cell ageing

11-Apr-2024

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A new study led by Nobel Prize-winning scientist Carol Greider investigates telomeres, the protective caps on the ends of our chromosomes which play a crucial role in cell division and health.

Researchers have long believed that telomeres across all chromosomes fall within a similar length range. However, this study upends that understanding.

Using cutting-edge DNA sequencing technology, Greider's team found that telomeres on specific chromosomes can be much longer or shorter than the average.

This suggests a more complex system for regulating telomere length than we previously thought.

Telomere length is directly linked to health. Telomeres that are too short contribute to age-related diseases, while overly long telomeres are associated with some cancers.

Uncovering the precise mechanisms controlling telomere length could lead to new drug targets for preventing diseases.

This breakthrough was made possible by a technique called nanopore sequencing, co-invented at the University of California which provides incredibly precise DNA readings.

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Carol Greider

Professor of Molecular Biology & Genetics at The Johns Hopkins University School of Medicine.

University of California

Public research university with 10 campuses and 5 medical centres

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Telomeres
Telomeres are different lengths than scientists previously thought