Key points from article :
Delivery of extracellular vesicles harvested from stem cells may be a good replacement for first generation stem cell therapies.
Whole transplanted cells produce benefits via signaling before dying.
Extracellular vesicles are an easier, cheaper approach from a logistical point of view.
Old animals intravenously received small extracellular vesicles (sEVs) derived from adipose mesenchymal stem cells (ADSCs) of young animals.
None of the old ADSCs-sEVs treated mice were frail, compared to 40% of old control mice.
ADSCs-sEVs induced pro-regenerative effects and a decrease in oxidative stress, inflammation, and senescence markers.
Effect on the functionality of old mice was lost two months after treatment.
Research by University of Valencia, led by Consuelo Borrás, preprint available on bioRxiv .
