Join the club for FREE to access the whole archive and other member benefits.

Josh Mitteldorf stakes his reputation on major rejuvenation in a mammal

Imagine halving your age with 4 simple injections - at the very least it will buy more time

11-May-2020

Key points from article :

Treatment used four intravenous doses derived from a fraction of blood plasma - nothing was removed from old rats blood.

Harold Katcher was part of a team that discovered the breast cancer gene, brca1.

Katcher believes that, to a large extent, aging is coordinated system-wide via signal molecules in the blood.

There are thousands of constituents represented in tiny concentrations in blood plasma.

Two years ago he set up a lab in Bangalore using funding from Akshay Sanghavi.

Encouraging results using a fraction extracted from the blood of young rats secured another funder.

Further details are pending IPR protection and financing for human trials.

Developed a set of six methylation clocks specialized to rats, one of which is calibrated across species.

Average rejuvenation across four tissues was 54.2% - so it halved the epigenetic age.

Other positive measures include IL-6 (inflammation), glutathione, cognitive function, HDL cholesterol, blood triglycerides and glucose.

Mentioned in this article:

Click on resource name for more details.

Harold Katcher

Professor at University of Maryland - working on rejuvenation blood factors

Josh Mitteldorf

Evolutionary biologist and author of the Playing the Game for a Longer Life blog

Nugenics Research

Funded Harold Katcher's rat rejuvenation trial using blood fraction

Topics mentioned on this page:
Young Blood, Epigenetics
Josh Mitteldorf stakes his reputation on major rejuvenation in a mammal