Key points from article :
A molecule called Klotho was able to improve muscle strength.
“Supplementation with Klotho may attenuate the development of sarcopenia,” - Zachary Clemens, co-first author.
Compared changes in the structure, function and gene activity in skeletal muscle across the lifespan in mice.
Found a progressive disruption in genes associated with the hallmarks of aging from the young to the oldest-old mice.
Applying Klotho after muscle injury reduced scarring and increased structures associated with force production.
Had better muscle function and whole-body endurance improved two-fold.
But this was only seen in the old mice, and not in the oldest-old animals.
The oldest-old mice showed a dysregulated gene response.
“Future studies to determine whether boosting Klotho levels at a younger age could prevent muscle declines into old, and even oldest-old, age,” -Fabrisia Ambrosio, senior author.
Study by University of Pittsburgh published in eLife.
