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Klotho protein reversed muscle ageing in old, but not older mice

Potential future treatment strategy to prevent sarcopenia when supplemented at a young age


Key points from article :

A molecule called Klotho was able to improve muscle strength.

“Supplementation with Klotho may attenuate the development of sarcopenia,” - Zachary Clemens, co-first author.

Compared changes in the structure, function and gene activity in skeletal muscle across the lifespan in mice.

Found a progressive disruption in genes associated with the hallmarks of aging from the young to the oldest-old mice.

Applying Klotho after muscle injury reduced scarring and increased structures associated with force production.

Had better muscle function and whole-body endurance improved two-fold.

But this was only seen in the old mice, and not in the oldest-old animals.

The oldest-old mice showed a dysregulated gene response.

“Future studies to determine whether boosting Klotho levels at a younger age could prevent muscle declines into old, and even oldest-old, age,” -Fabrisia Ambrosio, senior author.

Study by University of Pittsburgh published in eLife.

Mentioned in this article:

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eLife Sciences

Non-profit journal publishing work in all areas of biology and medicine

Fabrisia Ambrosio

Director of Rehabilitation at UPMC International, Associate Professor at the University of Pittsburgh

University of Pittsburgh

Public state-related research university

Zachary Glass

Formulation scientist at Verve therapeutics

Topics mentioned on this page:
Sarcopenia, Ageing Research