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Scientists reverse cellular ageing while maintaining cell's identity

How long will it take until this can be applied to human cells inside the body?

24-Mar-2020

Key points from article :

Scientists rejuvenate human cells by reprogramming them in to a youthful state.

Development of embryonic stem cells into specific cell types are done by marks on their epigenome.

These activate necessary genes while locking down all other genes, thus establishing cell's identity.

Four Yamanaka factors erase cell's identity and reverts it back to an induced pluripotent stem cell.

Small doses of Yamanaka factors retains cell’s identity and returns it to a youthful state.

Successful in restoring youthful state in aged human cartilage cells and muscle stem cells.

Potential treatment for age related conditions such as osteoarthritis and muscle wasting.

Research by Stanford University, published in Nature Communications.

Mentioned in this article:

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Juan Carlos Izpisua Belmonte

Professor at the Salk Institute for Biological Studies, Director at San Diego Institute of Science, Altos Labs

Leonard Guarente

Novartis Professor at MIT.

Nature Communications

Journal covering all topics in physics, chemistry, and biology

Shinya Yamanaka

Professor, Nobel prize winner and stem cell researcher, Senior scientific advisor to Altos Labs

Stanford University

Private research university, one of the world's leading research and teaching institutions

Tapash Jay Sarkar

Scientist at Stanford University, Co-Founder and Head Of Research at Turn Biotechnologies

Thomas A. Rando

Professor of Neurology at Stanford University

Turn Biotechnologies

Focused on restoring cells’ youthful vigor to repair damage caused by the aging process

Vittorio Sebastiano

Assistant Professor of Obstetric and Gynaecology at the Stanford University School of Medicine

Topics mentioned on this page:
Stem Cells, Musculoskeletal