Scientists reverse cellular ageing while maintaining cell's identity

24-Mar-2020
KEY POINTS FROM ARTICLE:

Scientists rejuvenate human cells by reprogramming them in to a youthful state.
Development of embryonic stem cells into specific cell types are done by marks on their epigenome.
These activate necessary genes while locking down all other genes, thus establishing cell's identity.
Four Yamanaka factors erase cell's identity and reverts it back to an induced pluripotent stem cell.
Small doses of Yamanaka factors retains cell’s identity and returns it to a youthful state.
Successful in restoring youthful state in aged human cartilage cells and muscle stem cells.
Potential treatment for age related conditions such as osteoarthritis and muscle wasting.
Research by Stanford University, published in Nature Communications.

How long will it take until this can be applied to human cells inside the body?

Mentioned in this article:

Resource Juan Carlos Izpisua Belmonte

Resource Leonard Guarente - Novartis Professor at MIT.

Resource Nature Communications - Journal covering all topics in physics, chemistry, and biology.

Resource Shinya Yamanaka - Professor, Nobel prize winner and stem cell researcher.

Resource Stanford University

Resource Tapash Jay Sarkar - Scientist at Stanford University

Resource Thomas A. Rando - Professor of Neurology at Stanford University

Resource Turn.bio - Company dedicated to Reversing Aging by Reprogramming Cells.

Resource Vittorio Sebastiano - Assistant Professor of Obstetric and Gynaecology,

Read full article on New York Times website
More Stem Cells information, news and resources
More Musculoskeletal information, news and resources