Scientists reverse cellular ageing while maintaining cell's identity
Scientists rejuvenate human cells by reprogramming them in to a youthful state.
Development of embryonic stem cells into specific cell types are done by marks on their epigenome.
These activate necessary genes while locking down all other genes, thus establishing cell's identity.
Four Yamanaka factors erase cell's identity and reverts it back to an induced pluripotent stem cell.
Small doses of Yamanaka factors retains cell’s identity and returns it to a youthful state.
Successful in restoring youthful state in aged human cartilage cells and muscle stem cells.
Potential treatment for age related conditions such as osteoarthritis and muscle wasting.
Research by Stanford University, published in Nature Communications.
Mentioned in this article:
Leonard Guarente - Novartis Professor at MIT.
Nature Communications - Journal covering all topics in physics, chemistry, and biology.
Shinya Yamanaka - Professor, Nobel prize winner and stem cell researcher.
Tapash Jay Sarkar - Scientist at Stanford University
Thomas A. Rando - Professor of Neurology at Stanford University
Turn.bio - Company dedicated to Reversing Aging by Reprogramming Cells.
Vittorio Sebastiano - Assistant Professor of Obstetric and Gynaecology,