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Calorie Restriction

The only proven way of currently extending life expectancy in a variety of mammals is undernourishment (not malnourishment) but requires further study to see whether it has undesirable side effects.

Long lived species have less response to famine so, according to Aubrey de Grey, not likely to have a big impact in humans.

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Recent News

Rapamycin might not be an alternative for calorie restriction

Lifespan.io (LEAF) - 27-Jan-2021

Failed to mimic dietary restriction pathways on extending lifespan in progeroid mice

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Metabolic confusion diet probably has same effect as intermittent fasting

The Conversation (UK) - 08-Dec-2020

Metabolic confusion diet may have other health benefits than just weight loss

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Extending the healthspan without restricting calorie intake

Medical News Today - 13-Sep-2020

Metabolites vital for pro-longevity effect of calorie restriction can help develop drugs

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