Calorie Restriction
The only proven way of currently extending life expectancy in a variety of mammals is undernourishment (not malnourishment) but requires further study to see whether it has undesirable side effects.
Long lived species have less response to famine so, according to Aubrey de Grey, not likely to have a big impact in humans.
Laboratory mice primarily die from cancer, so any treatment that reduces cancer incidence is likely to have an impact on average lifespan even if not affecting the underlying ageing damage.
Resources
Click on resource name for more details.
CR Society International
Nonprofit organization focused on extending human longevity through calorie restriction
Fasting & Aging: Why Women are Different
04-Nov-2022
Oxford Longevity Project webinar about fasting and difference between men and women with Dr. Stephanie Estima and Abhinav Diwan
Michael Rae
Science Writer at SENS Research Foundation, Ex-Board Member of the Calorie Restriction Society
The Longevity Diet
A book written by Brian M. Delaney and Lisa Walford that explains in practical terms the concept of calorie restriction
Dr. Satchin Panda on Practical Implementation of Time-Restricted Eating & Shift Work Strategies
2 hour interview with Dr. Rhonda Patrick (FoundMyFitness) on YouTube
The Switch: Ignite Your Metabolism with Intermittent Fasting, Protein Cycling, and Keto
Book about food and dieting by James W. Clement.
Leonard P. Guarente on NAD, Sirtuins and Aging
Explains NAD+ synthesis is circadian, and how SIRT1 is critical in ISCs - 2016 Roy Walford lecture
Recent News
University of Alabama at Birmingham looking for IF and CR participants for new study
University of Alabama at Birmingham (UAB) - 10-Oct-2022
Will look at whether health and ageing improves with calorie restriction or intermittent fasting
Read more...Low-calorie diet during active period of the cycle increased lifespan in mice
UT Southwestern Medical Center - 05-May-2022
Triple the effect seen over simply restricting calorie intake
Read more...Limiting calories rewires immuno-metabolic function for longer healthspan in humans
GEN News - 14-Feb-2022
Protein produced by macrophages was identified as a key player of calorie restriction
Read more...Exercise paired with intermittent fasting is the best way for fat loss
University of Toronto - 07-Feb-2022
Experts share the science, benefits, best timings, and other tips of intermittent fasting
Read more...Feeding dogs once daily might improve health and cognitive function
Newsweek - 16-Nov-2021
This is another indicator that time restricted eating (TRE) has benefits in mammals
Read more...
