Calorie Restriction
The only proven way of currently extending life expectancy in a variety of mammals is undernourishment (not malnourishment) but requires further study to see whether it has undesirable side effects.
Long lived species have less response to famine so, according to Aubrey de Grey, not likely to have a big impact in humans.
Laboratory mice primarily die from cancer, so any treatment that reduces cancer incidence is likely to have an impact on average lifespan even if not affecting the underlying ageing damage.
Calorie Restriction News
Eating less activates the gene OXR1 which controls brain ageing and lifespan
Buck Institute - 11-Jan-2024
Research sheds light on the benefits of calorie restriction
Read more...Eating less, living longer: the positive effects of calorie restriction
International Institute on Ageing (INIA) - 16-Oct-2023
Modest calorie reduction can activate genes for healthy ageing
Read more...Calorie restriction and its effect on DNA methylation
Live Forever Club - 03-Mar-2023
Analysis of CALERIE trial shows a slowing down in the pace of ageing, but no immediate reduction in biological age
Read more...University of Alabama at Birmingham looking for IF and CR participants for new study
University of Alabama at Birmingham (UAB) - 10-Oct-2022
Will look at whether health and ageing improves with calorie restriction or intermittent fasting
Read more...Calorie Restriction Resources
Click on resource name for more details.
CR Society International
Nonprofit organization focused on extending human longevity through calorie restriction
Michael Rae
Science Writer at SENS Research Foundation, Ex-Board Member of the Calorie Restriction Society
The CR Way: Using the Secrets of Calorie Restriction for a Longer, Healthier Life
A revolutionary diet that provides the body with fewer calories than is traditionally required written by Paul McGlothin
The Longevity Diet
A book written by Brian M. Delaney and Lisa Walford that explains in practical terms the concept of calorie restriction
Leonard P. Guarente on NAD, Sirtuins and Aging
Explains NAD+ synthesis is circadian, and how SIRT1 is critical in ISCs - 2016 Roy Walford lecture