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Calorie Restriction

The only proven way of currently extending life expectancy in a variety of mammals is undernourishment (not malnourishment) but requires further study to see whether it has undesirable side effects.

Long lived species have less response to famine so, according to Aubrey de Grey, not likely to have a big impact in humans.

Resources

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Institute

Nonprofit organization focused on extending human longevity through calorie restriction

Video

Explains NAD+ synthesis is circadian, and how SIRT1 is critical in ISCs - 2016 Roy Walford lecture

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Recent News

New study responsible for the metabolic benefits of a Calorie restriction diet.

University of Wisconsin-Madison - 18-Oct-2021

Fasting alone recapitulates the effects of Calorie restriction

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Calorie restriction slows age-related stem cell exhaustion, improving overall health

Lifespan.io (LEAF) - 29-Sep-2021

Many studies underlined beneficial effects of calorie restriction in various tissues of mice

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Study finds multiple health benefits from time restricted eating (TRE)

EurekAlert! - 17-Aug-2021

Strong protection against fatty liver disease seen in mice regardless of age and sex

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Long-term caloric restriction prevents age-related adiposity in aged mice

Lifespan.io (LEAF) - 02-Jul-2021

Targeting SA-T cells: A promising intervention to control age-related chronic diseases

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Eating less than 800 calories a day favoured weight loss via hungry pathogens

ScienceAlert - 27-Jun-2021

Long-term safety of the diet is questionable as it alters the healthy gut microbiome

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