Calorie Restriction
The only proven way of currently extending life expectancy in a variety of mammals is undernourishment (not malnourishment) but requires further study to see whether it has undesirable side effects.
Long lived species have less response to famine so, according to Aubrey de Grey, not likely to have a big impact in humans.
Resources
Tap on icon for description, click on resource name for more details.
Nonprofit organization focused on extending human longevity through calorie restriction
Book about food and dieting by James W. Clement.
Explains NAD+ synthesis is circadian, and how SIRT1 is critical in ISCs - 2016 Roy Walford lecture
Recent News
Long-term caloric restriction prevents age-related adiposity in aged mice
Lifespan.io (LEAF) - 02-Jul-2021
Targeting SA-T cells: A promising intervention to control age-related chronic diseases
Read more...Eating less than 800 calories a day favoured weight loss via hungry pathogens
ScienceAlert - 27-Jun-2021
Long-term safety of the diet is questionable as it alters the healthy gut microbiome
Read more...Food odour nullifies lifespan benefits of dietary restriction in nematodes
Lifespan.io (LEAF) - 29-Apr-2021
You may have to avoid smelling, not just eating, food for CR to be effective
Read more...A low-calorie diet maintains youthful gut state & improves lifespan
Fight Aging! - 24-Mar-2021
Calorie restriction prevents age-related changes to the gut microbiome in mice
Read more...Rapamycin might not be an alternative for calorie restriction
Lifespan.io (LEAF) - 27-Jan-2021
Failed to mimic dietary restriction pathways on extending lifespan in progeroid mice
Read more...
