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Calorie Restriction

The only proven way of currently extending life expectancy in a variety of mammals is undernourishment (not malnourishment) but requires further study to see whether it has undesirable side effects.

Long lived species have less response to famine so, according to Aubrey de Grey, not likely to have a big impact in humans.

Laboratory mice primarily die from cancer, so any treatment that reduces cancer incidence is likely to have an impact on average lifespan even if not affecting the underlying ageing damage.

Calorie Restriction News

Eating less activates the gene OXR1 which controls brain ageing and lifespan

Buck Institute - 11-Jan-2024

Research sheds light on the benefits of calorie restriction


Eating less, living longer: the positive effects of calorie restriction

International Institute on Ageing (INIA) - 16-Oct-2023

Modest calorie reduction can activate genes for healthy ageing


Calorie restriction and its effect on DNA methylation

Live Forever Club - 03-Mar-2023

Analysis of CALERIE trial shows a slowing down in the pace of ageing, but no immediate reduction in biological age


University of Alabama at Birmingham looking for IF and CR participants for new study

University of Alabama at Birmingham (UAB) - 10-Oct-2022

Will look at whether health and ageing improves with calorie restriction or intermittent fasting

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Calorie Restriction Resources

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CR Society International

Nonprofit organization focused on extending human longevity through calorie restriction

Michael Rae

Science Writer at SENS Research Foundation, Ex-Board Member of the Calorie Restriction Society

The CR Way: Using the Secrets of Calorie Restriction for a Longer, Healthier Life


A revolutionary diet that provides the body with fewer calories than is traditionally required written by Paul McGlothin

The Longevity Diet


A book written by Brian M. Delaney and Lisa Walford that explains in practical terms the concept of calorie restriction

Leonard P. Guarente on NAD, Sirtuins and Aging

Explains NAD+ synthesis is circadian, and how SIRT1 is critical in ISCs - 2016 Roy Walford lecture

More Calorie Restriction resources