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Calorie Restriction

The only proven way of currently extending life expectancy in a variety of mammals is undernourishment (not malnourishment) but requires further study to see whether it has undesirable side effects.

Long lived species have less response to famine so, according to Aubrey de Grey, not likely to have a big impact in humans.

Resources

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Institute

Nonprofit organization focused on extending human longevity through calorie restriction

Video

Explains NAD+ synthesis is circadian, and how SIRT1 is critical in ISCs - 2016 Roy Walford lecture

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Recent News

Long-term caloric restriction prevents age-related adiposity in aged mice

Lifespan.io (LEAF) - 02-Jul-2021

Targeting SA-T cells: A promising intervention to control age-related chronic diseases

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Eating less than 800 calories a day favoured weight loss via hungry pathogens

ScienceAlert - 27-Jun-2021

Long-term safety of the diet is questionable as it alters the healthy gut microbiome

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Food odour nullifies lifespan benefits of dietary restriction in nematodes

Lifespan.io (LEAF) - 29-Apr-2021

You may have to avoid smelling, not just eating, food for CR to be effective

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A low-calorie diet maintains youthful gut state & improves lifespan

Fight Aging! - 24-Mar-2021

Calorie restriction prevents age-related changes to the gut microbiome in mice

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Rapamycin might not be an alternative for calorie restriction

Lifespan.io (LEAF) - 27-Jan-2021

Failed to mimic dietary restriction pathways on extending lifespan in progeroid mice

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