Calorie Restriction
The only proven way of currently extending life expectancy in a variety of mammals is undernourishment (not malnourishment) but requires further study to see whether it has undesirable side effects.
Long lived species have less response to famine so, according to Aubrey de Grey, not likely to have a big impact in humans.
Laboratory mice primarily die from cancer, so any treatment that reduces cancer incidence is likely to have an impact on average lifespan even if not affecting the underlying ageing damage.
Resources
Click on resource name for more details.
CR Society International
Nonprofit organization focused on extending human longevity through calorie restriction
The Longevity Diet
A book written by Brian M. Delaney and Lisa Walford that explains in practical terms the concept of calorie restriction
The Switch: Ignite Your Metabolism with Intermittent Fasting, Protein Cycling, and Keto
Book about food and dieting by James W. Clement
Fasting & Aging: Why Women are Different
04-Nov-2022
Oxford Longevity Project webinar about fasting and difference between men and women with Dr. Stephanie Estima and Abhinav Diwan
Michael Rae
Science Writer at SENS Research Foundation, Ex-Board Member of the Calorie Restriction Society
Dr. Satchin Panda on Practical Implementation of Time-Restricted Eating & Shift Work Strategies
2 hour interview with Dr. Rhonda Patrick (FoundMyFitness) on YouTube
Leonard P. Guarente on NAD, Sirtuins and Aging
Explains NAD+ synthesis is circadian, and how SIRT1 is critical in ISCs - 2016 Roy Walford lecture
Recent News
Calorie restriction and its effect on DNA methylation
Live Forever Club - 03-Mar-2023
Analysis of CALERIE trial shows a slowing down in the pace of ageing, but no immediate reduction in biological age
Read more...Effects of intermittent fasting: An exploration
Live Forever Club - 31-Jan-2023
12 months of IF results in a range of biomarker improvements, but no significant reduction in inflammatory markers
Read more...Poor eating habits can increase your risk of early death, study finds
Neuroscience News - 22-Nov-2022
Skipping meals or eating meals within 4.5 hours may lead to heart disease or death
Read more...University of Alabama at Birmingham looking for IF and CR participants for new study
University of Alabama at Birmingham (UAB) - 10-Oct-2022
Will look at whether health and ageing improves with calorie restriction or intermittent fasting
Read more...Low-calorie diet during active period of the cycle increased lifespan in mice
UT Southwestern Medical Center - 05-May-2022
Triple the effect seen over simply restricting calorie intake
Read more...
