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New study leading towards permanent youthful immune function

18-Oct-2021

Key points from article :

Hematopoietic stem cells (HSCs) are driven towards one of three fates: erythroid, myeloid, or lymphoid.

Myeloid cells are responsible for innate immunity, including macrophages, megakaryocytes, and neutrophils.

Lymphoid cell fate was increased in old mice with NR supplementation.

Myeloid cell fate was decreased, thus restoring the balance more towards youth.

NR had little discernable effect on young wild-type mice in most of these categories.

Lymphoid cell counts were practically identical, and neutrophil count was not decreased.

Researchers found myeloid-related genes in cells given NR were downregulated.

While lymphoid-related genes were upregulated, showing the broad effects of NAD+ supplementation in living mice.

This research leads towards ways to restore cell fate to youthful immune function.

Research by National Institute on Aging, led by Isabel Beerman, published in Nature Aging.

Significant alteration in lineage potential by NR treatment in mice

Mentioned in this article:

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Academic

Investigator at National Institute on Aging / National Institutes of Health

Institute

Conducting and supporting research on aging and the health and well-being of older people.

Journal

Journal spanning the entire spectrum of research into aging