Key points from article :
Hematopoietic stem cells (HSCs) are driven towards one of three fates: erythroid, myeloid, or lymphoid.
Myeloid cells are responsible for innate immunity, including macrophages, megakaryocytes, and neutrophils.
Lymphoid cell fate was increased in old mice with NR supplementation.
Myeloid cell fate was decreased, thus restoring the balance more towards youth.
NR had little discernable effect on young wild-type mice in most of these categories.
Lymphoid cell counts were practically identical, and neutrophil count was not decreased.
Researchers found myeloid-related genes in cells given NR were downregulated.
While lymphoid-related genes were upregulated, showing the broad effects of NAD+ supplementation in living mice.
This research leads towards ways to restore cell fate to youthful immune function.
Research by National Institute on Aging, led by Isabel Beerman, published in Nature Aging.
