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Invisible stem cells treat disease without triggering immune response

Genetically-modified stem cells avoid immune rejection, paving way for universal therapies for everyone

28-Feb-2024

Key points from article :

Researchers are developing stem cells that can evade the immune system's recognition mechanisms.

Gene-editing techniques, such as CRISPR, are being used to modify stem cells.

One challenge is that the immune system can still attack these cells if they don't have the proper MHC signatures.

To overcome this, researchers are introducing genes that encode specific MHC antigens and make them safer.

Optimal approach for immune-evasion may vary depending on the disease.

ViaCyte trials placed encapsulated immune-evasive cells beneath the skin, so can be swiftly retrieved in case of unanticipated issues.

It is still in the early stages of development, but has the potential to revolutionize the field of medicine.

Article published in Nature journal.

Mentioned in this article:

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Nature

Scientific journal covering research from a variety of academic disciplines, mostly in science and technology

ViaCyte

Regenerative medicine company dedicated to developing a functional cure for type 1 diabetes.

Topics mentioned on this page:
Stem Cells, Gene Therapy
Invisible stem cells treat disease without triggering immune response