Key points from article :
Evidence shows that gut microbiome (GM) globally governs host physiology.
Associations between perturbations of GM, complications of bone marrow transplant found.
Cancer patients with more diverse GM had better survival outcomes than those with lower diversity.
Providing interventions to balance GM prior to transplants enhance patients’ health.
Weizmann Institute developed a machine-learning algorithm to integrate microbiome data.
As well as to evaluate an individual’s glycemic response to identical foods.
Team showed that a host’s genetics has only a “minor role” in GM’s composition.
Data show GM is altered in individuals with various noncommunicable diseases (NCDs).
Some NCDs could have microbial component and, if so, might be communicable via microbiota.
One application has advanced clinically—fecal microbiota transplantation (FMT).
Facing many hurdles, it aims to treat recurrent Clostridioides difficile infections.
Promising but true clinical impact still a long road for GM studies.
