Join the club for FREE to access the whole archive and other member benefits.

Summary of Fabrizio d’Adda di Fagagna presentation at Longevity Med Summit


Ageing is a significant risk factor for various diseases, including cancer, and is associated with cellular dysfunction and chronic inflammation.

Senescent cells, which cannot proliferate, start secreting chemicals and pro-inflammatory cytokines, contributing to a state of inflammation and disease susceptibility.

The loss of cell homeostasis and the accumulation of DNA damage are believed to contribute to ageing and disease.

While DNA damage can be repaired, damage occurring in telomeres, the ends of linear chromosomes, is often not repaired due to evolutionary constraints.

Telomeres, when too short or damaged, activate the DNA damage response and lead to cellular dysfunction.

In mouse models with telomerase inactivation, treating them with antisense oligonucleotides resulted in the inactivation of DNA damage response and halted fibrosis progression.

Ongoing research involves studying various cell types in the bone marrow and spleen to understand the long-term consequences of telomere-related treatments.

Telomeres become sinks of irreparable damage - antisense oligonucleotides could potentially provide a fix

Mentioned in this article:

Click on resource name for more details.

Fabrizio d’Adda di Fagagna

Researcher at the National Research Council of Italy (CNR)

Longevity Med Summit

04-May-2023 to 05-May-2023

Annual gathering of the entire longevity ecosystem to tackle the aging problem

Summary of Fabrizio d’Adda di Fagagna presentation at Longevity Med Summit