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Telomere length may have protective effects against dementia-provide a pathway for future research

Associations between telomere length and endophenotypes could help treat neurodegenerative disease

22-Mar-2023

Key points from article :

Researchers have found associations between telomere length and endophenotypes, or markers, of neurodegenerative disease.

It suggests that longer telomeres may have protective effects against dementia.

As cells age and continue to divide, telomeres become progressively shorter.

Shorter telomeres are a marker of biological ageing and may increase the likelihood of age-related diseases such as dementia. 

Researchers compared telomere length in white blood cells with results from brain MRI scans and electronic health records from 31,661 UK Biobank participants.

Anya Topiwala, consultant psychiatrist said ‘Understanding the biological mechanisms that cause neurodegenerative disease ... slow down disease progression.’

The study was carried out at the University of Oxford and the results are published in PLOS ONE. 

Mentioned in this article:

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Anya Topiwala

Wellcome Trust CRCD Fellow and consultant psychiatrist.

PLOS ONE

This journal covers primary research from any discipline within science and medicine.

UK BioBank

UK Biobank is a national and international health resource registered as a charity in Scotland

University of Oxford

Collegiate research university and one of the world's leading universities

Topics mentioned on this page:
Telomeres, Mental Health
Telomere length may have protective effects against dementia-provide a pathway for future research