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miniPUMP - the next-best personalised human heart model for drug testing

Your cells as your own "organ-on-a-chip" model for heart disease

25-Apr-2022

Key points from article :

Scientist developed the next-best thing, in the form of a tiny mechanical heart powered by real cardiac cells.

Flat-bodied "cardiac miniaturized Precision-enabled Unidirectional Microfluidic Pump" – or miniPUMP is just 3 sq cm.

It replicates the function of a real heart's ventricle (lower chamber).

A scaffold made up of a series of linked concentric acrylic spirals.

These plastic based 3D minuscules are seeded with live human cardiomyocytes (heart muscle cells).

Patients could have miniPUMPs made from their own cells, to see how different medications might affect their heart specifically.

"If I take cells from you, I can see how the drug would react in you, because these are your cells," said the lead scientist, Christos Michas.

Same technology could one day be used to produce other so-called "organ-on-a-chip" devices, such as lungs and kidneys.

Research by Boston University led by Christos Michas, published in Science advances.

Mentioned in this article:

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Boston University

Private research university in Boston, Massachusetts

Christos Michas

Postdoctoral Associate in Biomedical Engineering at Boston University

Science Advances

Journal that publishes original research and reviews in all disciplines of science

Topics mentioned on this page:
Regenerative Medicine, Heart Disease