Key points from article :
Numerous diseases are associated with imbalance or dysfunction in the gut microbiome.
The development of effective live bacterial therapeutics may depend more on using and re-introducing native microbes.
The gut microflora provides an important point of access that allows modification of many physiological systems.
The re-engineered native bacteria serve as chassis to introduce therapeutics into the gut microbiome to treat or cure disease developing live bacterial therapeutics (LBTs).
“The lack of engraftment limits the use of LBTs for chronic conditions for curative effect ... in the gut microbiome,” said Amir Zarrinpar, assistant professor.
Long-term therapy in a mouse model of type 2 diabetes was found employing this method and reversing disease pathologies.
The study was conducted at the University of California San Diego School of Medicine and published in the online issue of Cell.
