Metformin misses the mark in PAD
Healio - 14-Nov-2025Walking performance in non-diabetic PAD patients remained unchanged despite metformin treatment
Join the club for FREE to access the whole archive and other member benefits.
Here is a round up of the current contenders for slowing or reducing aging. As research continues, and if/when they make real advancements in human trials (or at least human cells) I'll split them into their own pages with more analysis.

Diabetics who are on metformin actually seem to be living longer than nondiabetics who are not on it - Bill Gifford
David Sinclair has said he is taking it - but skips the pill on days that he exercises.
Non-sanctioned therapy used by athritis sufferers.
The Therapeutic use of Radon: A Biomedical Treatment in Europe; An “Alternative” Remedy in the United States - National Center for Biotechnology Information - 23-Sep-2006
Discusses the decision-making process involved in using radon, and compare the Montana radon health mine facilities with selected radon mines and spas in Europe.
A chemical produced by bacteria that has been shown to have immunosuppressive and antiproliferative properties. It is currently used in the prevention of transplant rejection and as a coronary stent coating, and is also being tested for certain cancers.
Walking performance in non-diabetic PAD patients remained unchanged despite metformin treatment
BBC finds untrained beauticians using dangerous high-strength bleach, putting consumers at risk
Private anti-aging clinics promise healthspan gains but risk science credibility
Rapamycin extended mouse lifespan by up to 28%, even when given in mid or late life, review finds
Click on resource name for more details.
Optispan podcast episode - Brad Stanfield discusses his journey from GP to longevity leader
Optispan podcast episode - Lithium and Rapamycin: new hope for Alzheimer’s
Optispan podcast episode - Longevity Conference Turns Risky After Peptide Use?
Longevity by design Podcast Episode - Dr. Nir Barzilai on longevity genes, aging biomarkers, and metformin
Optispan Podcast Episode - Dr. Alex and Dr. Jan explain why most anti-aging supplements fail to deliver results
Optispan podcast episode - Matt explores the hidden challenges within the longevity industry
When selecting a supplement, price is not the sole determining factor