Join the club for FREE to access the whole archive and other member benefits.

Fountains of Youth

Here is a round up of the current contenders for slowing or reducing aging. As research continues, and if/when they make real advancements in human trials (or at least human cells) I'll split them into their own pages with more analysis.

Metformin

Diabetics who are on metformin actually seem to be living longer than nondiabetics who are not on it - Bill Gifford

David Sinclair has said he is taking it - but skips the pill on days that he exercises.

Radiation Hormesis

Non-sanctioned therapy used by athritis sufferers.

The Therapeutic use of Radon: A Biomedical Treatment in Europe; An “Alternative” Remedy in the United States - National Center for Biotechnology Information - 23-Sep-2006
Discusses the decision-making process involved in using radon, and compare the Montana radon health mine facilities with selected radon mines and spas in Europe.

Rapamycin (aka sirolimus)

A chemical produced by bacteria that has been shown to have immunosuppressive and antiproliferative properties. It is currently used in the prevention of transplant rejection and as a coronary stent coating, and is also being tested for certain cancers.

Fountains of Youth News

Rapamycin tops NIH review of anti-aging drugs

Rapamycin tops NIH review of anti-aging drugs

UT Health San Antonio - 28-Aug-2025

Rapamycin extended mouse lifespan by up to 28%, even when given in mid or late life, review finds

Rapamycin can extend life in animals and reduce seizures

Rapamycin can extend life in animals and reduce seizures

Live Forever Club - 21-Jul-2025

More research and better safety tracking are needed before wider use

Can lifestyle changes really prevent diabetes long term?

Can lifestyle changes really prevent diabetes long term?

Live Forever Club - 22-Jun-2025

Lifestyle extended diabetes-free survival 3.5 years, metformin 2.5 years

Longevity clues: rapamycin shows lifespan boost

Longevity clues: rapamycin shows lifespan boost

New Scientist - 19-Jun-2025

Drug mimics life-extending effects of calorie restriction across multiple vertebrate species

More Fountains of Youth News

Fountains of Youth Resources

Click on resource name for more details.

Dr. Peter Attia: Training, Eating & Optimizing To Live Longer And Healthier In 2025

Optispan podcast episode - Matt and Peter Attia discuss strategies to enhance both healthspan and lifespan

Matt Kaeberlein reflects on "David Sinclair’s Longevity Lie"

Matt and Nick offers their perspective on "David Sinclair’s Longevity Lie"

DON’T Take Resveratrol Until You Watch This Video

Matt provides an in-depth review of the current research on resveratrol

Longevity Expert Sheds Light on common MISCONCEPTIONS for People’s’ Health

Matt addresses common misconceptions about longevity and healthspan

Charlatan

Amazon

America’s Most Dangerous Huckster, the Man Who Pursued Him, and the Age of Flimflam by Pope Brock

True Health Initiative

Creating a culture free of preventable chronic disease through a global consensus on the evidence-based truths of lifestyle as medicine

More Fountains of Youth resources
Topics covered in this page:
Fountains of Youth, Metformin, Rapamycin, Snake Oil