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Reversing epigenetic changes rejuvenated mice with progeria

Could turning back the clock on genes make us live much longer?

08-Aug-2019

Key points from article :

Reprogramming resets the epigenetic marks that turn genes on and off.

Changes in histones and methylation marks that accumulate in the cells with ageing are reset.

Possible to turn back ageing by reversing these epigenetic changes.

Succeeded in rejuvenating mice with progeria but has to test this on normal animal models.

The first human tests of these techniques are likely to happen in the next few years.

Research by Salk Institute for Biological Studies, published in the journal Cell.

Mentioned in this article:

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Cell

Scientific journal publishing research from many disciplines within the life sciences

Duke University

Private research university in Durham, North Carolina

Juan Carlos Izpisua Belmonte

Professor at the Salk Institute for Biological Studies, Director at San Diego Institute of Science, Altos Labs

Marcelo Wood

Professor of Neurobiology and Behavior at University of California.

Nature Communications

Journal covering all topics in physics, chemistry, and biology.

Salk Institute

Scientific research institute focused on neuroscience, genetics, immunology, plant biology and more

Spanish National Cancer Research Center (CNIO)

Center for cancer research, including diagnosis and treatments.

Topics mentioned on this page:
Rejuvenation, Fountains of Youth