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Engineered genes in gut bacteria might help you live longer

Green light activated E.coli genes, extending life in Caenorhabditis elegans

23-Dec-2020

Key points from article :

Light could be used to manipulate the metabolism of gut bacteria to prolong our lifespans.

Optogenetics, where cells are engineered to have genes that respond to light.

Optogenetics would benefit the health of human hosts, extend lifespan.

Used different colors of light to turn-on specific genes in the bacterium E. coli inside the intestine of a nematode worm.

Team created E. coli that would only produce colanic acid when exposed to green light.

Gut bacteria produced more colanic acid and their worm hosts lived slightly longer.

Colanic acid promotes longevity by helping mitochondria.

"The stronger the light, the longer the lifespan." - Meng Wang, biologist.

Controlling gut bacteria through optogenetics could reduce risk of certain conditions.

"Light is really the only signal that has enough precision to turn on bacterial genes..." - Jeffrey Tabor, researcher.

Study by Baylor College of Medicine and Rice University published in eLife Sciences.

Mentioned in this article:

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Baylor College of Medicine

Health sciences university

eLife Sciences

Non-profit journal publishing work in all areas of biology and medicine

Jeffrey Tabor

Associate Professor of Bioengineering at Rice University

Meng Wang

Professor at Baylor College of Medicine, Investigator at Howard Hughes Medical Institute

Rice University

Private research university in Houston, Texas

Topics mentioned on this page:
Microbiome, Medical Technology