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Key points from Arkadi Mazin's summary of 5 days of talks by geroscientists and biotech leaders


Key points from article :

Since 2019, ARDD has been held under the auspices of the University of Copenhagen.

James Kirkland - more than 80 clinical gerotherapeutic studies are underway; biomarkers that reliably react to interventions are needed

Thomas A. Rando - both induction of cyclin D1 and nhibition of TGFß restore functionality of aged muscle stem cells; plasma from exercised mice positively affects aspects of aging in age-matched non-exercised animals; supplementation with SAM rescues the regenerative potential of muscle stem cells

Michael Ringel -  geroscience is “not yet on the public radar”; the longevity field needs a strong grassroots movement

Nir Barzilai - gerotherapeutics must target more than one hallmark of aging; “do no harm”, taken too literally, “makes MDs conservative”; people on metformin had half the mortality rate and hospitalization with COVID; metformin might not be advised for younger healthy people

Alex Zhavoronkov - presented the new roboticized InSilico lab; Exelixis has licensed ISM3091, InSilico’s leading candidate drug for treating BCMA-mutated cancers

Tzipi Strauss - world’s first longevity clinic affiliated with a public hospital (Sheba Hospital); upcoming SHARP trial (n=1500) will include several interventions that are rigorously tested using a battery of biomarkers

Evelyne Bischof - imperative that high-quality longevity medicine eventually becomes available to all; argued for integrating longevity medicine into oncology decision making and guidelines

Andrea Maier - announced the opening of another hospital-affiliated longevity clinic (Alexandra Hospital in Singapore)

Bente Klarlund Pedersen - physical inactivity induces chronic systemic inflammation while exercise lowers it

Luigi Ferrucci - alternative splicing is an essential component of biology that plays an important role in responses to such stressors as scarcity of energy or cellular senescence; physical activity downregulates alternative splicing

Kelsey Moody - lipofuscin granules are the incomplete breakdown of damaged cellular structures; generally believed to be detrimental to cells

Anne Brunet - brain aging and rejuvenation; brain has some regenerative capacity due to several of its regions harboring stem cells

Sara Wickström - role of the extracellular matrix (ECM) in stem cell aging; old cells experience increased mechanical stress and remain in the quiescent state for much longer

Collin Ewald - faulty ECM contributes to numerous age-related diseases; restoring the healthy remodeling of collagen might be one of the most important goals for geroscience; reported on a small-scale pilot clinical trial of DracoBelle that boosts collagen production

David Sinclair - some elements of DSB repair, such as Sir2, also play an important role in maintaining chromatin stability; epigenomic dysregulation drives aging even when DSB repair is faithful and no harmful mutations occur; study of partial reprogramming using small molecules produced encouraging preliminary results

Morten Scheibye-Knudsen - trying to understand various trajectories of aging using unconventional data; males and females tend to have different trajectories; announced the founding of the Nordic Aging Society

Valter Longo - fasting-mimicking diet (FMD) leads to life extension and rejuvenation of the immune system in mic

João Passos - senescence markers used in studies are not present in every senescent cell; SASP can also differ considerably between senescent cell subtypes; senescence markers can be present in non-senescent cells; senescent cells should be identified via multi-marker approaches

Vadim Gladyshev - in order to target aging, scientists must identify multi-marker “signatures” of longevity; rejuvenation event (aka “the embryonic reset”) might hold the keys to understanding and eventually defeating aging

Mentioned in this article:

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Alex Zhavoronkov

CEO of InSilico Medicine & Deep Longevity. CSO of Biogerontology Research Foundation

Andrea Maier

Oon Chiew Seng Professor in Medicine, Director, Centre for Healthy Longevity, NUS

Anne Brunet

Professor of Genetics at Stanford University

ARDD 2023 - 10th Aging Research & Drug Discovery Meeting

28-Aug-2023 to 01-Sep-2023

Event about latest progress in the molecular, cellular and organismal basis of aging organized by University of Copenhagen

Bente Klarlund Pedersen

Professor at the University of Copenhagen and Motivational speaker

Collin Ewald

Assistant Professor at ETH Zurich, Founder of Swiss Society for Aging Research

David Sinclair

Harvard professor. Author of Lifespan.

Evelyne Bischof

Longevity physician at Human Longevity, Inc. and Associate professor at Shanghai University of Medicine and Health Sciences


Biotechnology company striving to accelerate the development of new medicines for difficult-to-treat cancers

James Kirkland

Researcher on different aging related diseases

Joao Passos

Associate Professor at Mayo Clinic

Kelsey Moody

CEO of Ichor Therapeutics focussed on drug discovery that impacts the pathways of aging

Luigi Ferrucci

Scientific Director at the National Institutes of Aging (NIA)

Morten Scheibye-Knudsen

Head of the Biology of Ageing Laboratory at the University of Copenhagen

Nir Barzilai

Founding director of the Institute for Aging Research

Nordic Aging Society (NAS)

Network that brings together Nordic leaders in the field of aging research

Sara Wickström

Professor of Cell and Developmental Biology at University of Helsinki

Thomas A. Rando

Professor of Neurology at Stanford University

Tzipi Strauss

Director of Department of Neonatology, Edmond & Lily Safra Children Hospital, Sheba Medical Center

University of Copenhagen

Public research university

Vadim Gladyshev

Professor of Medicine at Harvard Medical School

Valter Longo

Professor of Gerontology and Biological Sciences; Edna M. Jones Chair in Gerontology at USC Leonard Davis

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Ageing Research reports back from Aging Research and Drug Discovery Meeting (ARDD 2023)