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Crispr injection could reduce chance of heart attack


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Radical gene therapy that aims to drastically reduce the risk of heart attack.

Would change from a chronic care approach to a ‘one and done’ approach.

Therapy will modify genes in the liver that are involved in making low-density lipoprotein (LDL).

People with only one working copy of PCSK9 gene are remarkably resistant to heart attack.

Patients will be injected with nanolipids which use Crispr-Cas9 to disables PCSK9.

Researchers hope to trial the therapy within the next three years

Verve Therapeutics, which will develop the therapy, has received $58.5m from investors.

Verve Therapeutics treatment targets PCSK9 gene

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Martin Farrall

University Lecturer in Cardiovascular Genetics at Oxford University.

Sekar Kathiresan

Physician scientist, human geneticist and professor at Harvard Medical School.