Key points from article :
Researchers discovered ways to keep the blood manufacturing process flowing.
“If we manage to keep 90% of the cells in our body young, chances are that much of our body is going to be young,” - Angelo D’Alessandro, co-author of the study.
Targeted chaperone-mediated autophagy (CMA), mechanism responsible for degradation.
Pinpointing key protein (LAMP2A) that regulates CMA function whose expression and activity declines with age.
By introducing gamma linolenic acid (GLA) in the rodents’ diets, improved cell regeneration.
“We could make old mice look more like young mice in the capacity to generate new blood cells."
Could translate into reversing the aging process of HSCs in humans.
“Evidence links the impaired capacity to make young blood cells to the development of neurodegenerative diseases.”
Blood regeneration could also have a significant impact on blood donations.
Research by CU Anschutz Medical Campus published in the Journal Nature.
