Key points from article :
A series of whole blood exchange treatments were performed to partially replace blood from mice with Alzheimer’s disease-causing amyloids in their brains with blood from healthy mice.
Disease-modifying therapy for Alzheimer’s disease may involve the whole exchange of blood, which effectively decreased the formation of amyloid plaque in the brains of mice.
“This approach has the advantage that the disease can be treated in the circulation instead of in the brain,” said senior author Claudio Soto.
Manipulating circulating components in Alzheimer’s disease could be the key to solving the difficulty in delivering therapeutic agents across the blood-brain barrier.
Akihiko Urayama, the First author said, “ Blood vessels (in the brain) barrier is a very specialized interface between the brain and the systemic circulation.”
The study was carried out at UTHealth Houston and the results are published in Molecular Psychiatry.
