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A new enzyme discovered to reverse cellular ageing

Molecular simulations have discovered an enzyme with anti ageing and anti tumour effects


Key points from article :

An enzyme that could be targeted to reverse cellular senescence - discovered.

Molecules vital for reversing cellular senescence were identified.

A model simulating interactions between these molecules was developed.

A molecule, called PDK1, was investigated in incubated senescent skin fibroblasts and 3D skin models.

Blocking PDK1 restored the cells' ability to regenerate wounded skin.

PDK1 is over expressed in some tumours - inhibiting it will have both anti-aging and anti-cancer effects.

"Our research opens the door for a new generation that perceives ageing as a reversible biological phenomenon," - Prof Cho, KAIST.

Research by KAIST published in Proceedings of the National Academy of Sciences (PNAS).

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National university in Daejeon, South Korea.

Kwang-Hyun Cho

Professor at the Department of Bio and Brain engineering, Korea Advanced Institute of Science and Technology (KAIST)

Proceedings of the National Academy of Sciences (PNAS)

Multidisciplinary scientific journal, official journal of the National Academy of Sciences

Topics mentioned on this page:
Digital Modeling, Senescent Cells